Abstract
Electrocorticography and other intracranial neurophysiologic approaches in humans have grown substantially in recent years due to the complimentary information they can provide to other noninvasive recording modalities. Here, we describe the history of electrocorticography, the spectrum of recording techniques used to collect human neurophysiologic data, and important signal characteristics for use in research. Through a series of examples, we illustrate the use of these techniques in cognitive neuroscience and translational research with therapeutic applications in several neurologic and psychiatric disorders. Electrocorticography, together with other intracranial neurophysiological approaches, is a powerful window into the brain to understand human cognition, identify neuropsychiatric disease mechanisms, and provide therapeutic interventions through brain-computer interfaces and neurostimulation-based therapies.
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