Abstract
Accelerated intermittent theta-burst stimulation (aiTBS) is a safe and effective non-invasive neuromodulation therapy for treatment-resistant depression (TRD), yet the mechanisms underlying this effect are not well known. One potential mechanism involves neuroplastic changes to the cortex induced by repetitive stimulation. To assess this, we compared cortical thickness changes from baseline to immediate post-treatment in individuals undergoing aiTBS for TRD in a sham-controlled trial. We also examined the predictive value of early cortical changes on depression scores at one-month post-treatment.
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