Abstract
ObjectiveThis study evaluated alterations in cortical morphology in patients with transient global amnesia (TGA).Materials and MethodsDiagnoses of TGA occurred at our hospital. Evaluation involved a structured interview to obtain clinical information and a brain magnetic resonance imaging scan. We analyzed whole‐brain T1‐weighted MRI data using FreeSurfer 5.1. Measures of cortical morphology, such as thickness, surface area, volume, and curvature were compared between patients with TGA and healthy controls. We also quantified the correlations between clinical variables and each measure of abnormal cortical morphology.ResultsSeventy patients met the inclusion criteria. Compared to healthy controls, patients with TGA had significant alterations in cortical thickness in several regions of bilateral hemisphere. Moreover, several regions of cortical volumes in left hemisphere were significantly different between patients with TGA and healthy controls. In addition, there were significant correlations between the durations of episodes and cortical thickness, especially in the parietal cortex. However, there were no differences between groups in other measures of cortical morphology, including surface area and curvatures.ConclusionsWe observed significant alterations in cortical morphology in patients with TGA; these alterations are implicated in the pathogenesis of TGA.
Highlights
Transient global amnesia (TGA) is characterized by sudden onset of transient memory impairment with anterograde and partial retrograde amnesia, which lasts for several hours before resolving completely (Bartsch & Deuschl, 2010)
Recent research has demonstrated that cortical surface area and cortical thickness are independent and result from distinct neuro-biologic and genetic processes; these processes may contribute to the pathogenesis of neurological conditions such as TGA (Im et al, 2008; Panizzon et al, 2009; Rakic, 1988; Winkler et al, 2010)
We evaluated cortical morphology in patients with TGA, using surface-based analyses (SBA), with the aim to elucidate the mechanisms of TGA pathogenesis
Summary
Transient global amnesia (TGA) is characterized by sudden onset of transient memory impairment with anterograde and partial retrograde amnesia, which lasts for several hours before resolving completely (Bartsch & Deuschl, 2010). Some recent evidence suggests that structural abnormalities are associated with. The exact mechanisms have not been elucidated, these focal lesions in the hippocampus and subsequent perturbation of the hippocampal-neocortical memory system may be critical to the pathogenesis of TGA (Bartsch & Butler, 2013). Recent research has demonstrated that cortical surface area and cortical thickness are independent and result from distinct neuro-biologic and genetic processes; these processes may contribute to the pathogenesis of neurological conditions such as TGA (Im et al, 2008; Panizzon et al, 2009; Rakic, 1988; Winkler et al, 2010). We evaluated cortical morphology in patients with TGA, using SBA, with the aim to elucidate the mechanisms of TGA pathogenesis. We quantified the correlations between clinical variables and each measure of abnormal cortical morphology
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