Cortical microstructure and estimated bone strength in young amenorrheic athletes, eumenorrheic athletes and non-athletes

Abstract

ContextLower bone density in young amenorrheic athletes (AA) compared to eumenorrheic athletes (EA) and non-athletes may increase fracture risk during a critical time of bone accrual. Finite element analysis (FEA) is a unique tool to estimate bone strength in vivo, and the contribution of cortical microstructure to bone strength in young athletes is not well understood. ObjectiveWe hypothesized that FEA-estimated stiffness and failure load are impaired in AA at the distal radius and tibia compared to EA and non-athletes despite weight-bearing exercise. Design and settingCross-sectional study; Clinical Research Center Subjects34 female endurance athletes involved in weight-bearing sports (17 AA, 17 EA) and 16 non-athletes (14–21years) of comparable age, maturity and BMI Outcome measuresWe used HR-pQCT images to assess cortical microarchitecture and FEA to estimate bone stiffness and failure load. ResultsCortical perimeter, porosity and trabecular area at the weight-bearing tibia were greater in both groups of athletes than non-athletes, whereas the ratio (%) of cortical to total area was lowest in AA. Despite greater cortical porosity in EA, estimated tibial stiffness and failure load was higher than in non-athletes. However, this advantage was lost in AA. At the non-weight-bearing radius, failure load and stiffness were lower in AA than non-athletes. After controlling for lean mass and menarchal age, athletic status accounted for 5–9% of the variability in stiffness and failure load, menarchal age for 8–23%, and lean mass for 12–37%. ConclusionAA have lower FEA-estimated bone strength at the distal radius than non-athletes, and lose the advantage of weight-bearing exercise seen in EA at the distal tibia.