Abstract
Stress exposures, as well as dysregulated psychological and physiological responses to stress, are implicated in psychiatric disorders including disorders of mood, anxiety and cognition, with associated altered functioning in brain regions including the ventromedial prefrontal cortex (vmPFC) and dorsolateral prefrontal cortex (dlPFC). Pre-clinical studies suggest that GABA, the primary inhibitory neurotransmitter in the brain, modulates response to stress, including hypothalamic-pituitary-adrenal (HPA-axis) function. In humans, one study examining GABA levels in the nucleus accumbens demonstrated a negative correlation with perceived situational stress. The goal of the current study was to examine the relationship between perceived stress and in vivo measurements of GABA in prefrontal cortical control regions.
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