Abstract

Late-life depression (LLD) has major public health consequences given its association with serious disability, mortality in the medically ill elderly, and an increased rate of completed suicide. Despite the availability of effective antidepressant agents, many patients with LLD are refractory to treatment. Cognitive impairment is also a common feature of LLD and frequently persists even after mood symptom remission. Furthermore, substantial evidence indicates that LLD is both a risk factor and/or a prodrome of dementia including Alzheimer's disease (AD).

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