Cortical and subcortical correlates of intraindividual variability in reaction time

Abstract

Here we investigated the neuroanatomical correlates of intraindividual variability (IIV) of reaction time. 83 healthy young adults underwent MRI acquisition, and omnibus, PCA-based IIV and median RT (mRT) scores were obtained from a set of three RT tasks (verbal, quantitative, and spatial) developed after Sternberg’s memory search paradigm. Brain morphology was thoroughly characterized by means of state-of-the-art techniques, including cortical surface-based morphometry, subcortical shape analysis, and diffusion-based voxelwise analysis of white mater integrity. Results revealed that IIV, but not mRT, was associated regionally with cortical morphology of prefrontal and cingulate areas at a trend level (FWE-corrected P P P