Abstract
Refractory periods of the visual system were investigated in 12 healthy subjects by simultaneously recording retinal (ERG) and cortical (VEP) evoked electrical activity. Double-flash stimuli were presented at different interstimulus intervals, and response components evoked by the second flash were analyzed in detail, and related to psychophysical detection thresholds. With short interstimulus intervals ERG b-wave peak latencies were increased and b-wave amplitudes were significantly reduced, while P100 component latencies of the VEP were significantly influenced only at long interstimulus intervals. Regression analysis of the individual data as well as analysis of the retinocortical transmission times showed that the cortical latency changes were not simply caused by changes on the level of the retina. Additional influences of the interstimulus interval on nonretinal structures of the human visual system must be assumed. The subjective psychophysical detection thresholds were significantly higher than the threshold values at which reliable electrical or cortical response components could be elicited.
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