Corrosion resistance and tunable release of ciprofloxacin-loaded multilayers on magnesium alloy: Effects of SiO2 nanoparticles

Abstract

Complications related to corrosion and infection of magnesium (Mg) implants are encountered by physical barrier and local drug delivery system. In this work, the multilayer films composed of ciprofloxacin (CIP) and SiO2 nanoparticles were fabricated on Mg alloys by the spin-spray layer-by-layer assembly method. The resultant films were characterized via FT-IR, XPS, SEM and EDS techniques. The corrosion behaviors of the multilayer films were investigated via electrochemical tests and hydrogen evolution experiment. The obtained films showed corrosion resistance, self-healing ability, antibacterial efficacy and a prolonged release profile. The results also suggested that the loading dosage and the release rate of CIP could be controlled by the assembly parameters. Moreover, the in vitro release kinetics of CIP from the multilayer films could be fitted with the pseudo-second-order model.