Corrosion Behavior and Biological Activity of Micro Arc Oxidation Coatings with Berberine on a Pure Magnesium Surface

Liting Mu,Zhen Ma,Shidan Yuan,Jingyan Wang,Muqin Li

doi:10.3390/coatings10090837

Abstract

Bone tissue repair materials can cause problems such as inflammation around the implant, slow bone regeneration, and poor repair quality. In order to solve these problems, a coating was prepared by ultrasonic micro-arc oxidation and self-assembly technology on a pure magnesium substrate. We studied the effect of berberine on the performance of the ultrasonic micro-arc oxidation/polylactic acid and glycolic acid copolymer/berberine (UMAO/PLGA/BR) coating. The chemical and morphological character of the coating was analyzed using scanning electron microscopy, X-ray diffraction, and X-ray photoelectron spectroscopy. The corrosion properties were studied by potentiodynamic polarization and electrochemical impedance spectroscopy in a simulated body fluid. The cumulative release of drugs was tested by high-performance liquid chromatography. The results indicate that different amounts of BR can seal the corrosion channel to different extents. These coatings have a self-corrosion current density (Icorr) at least one order of magnitude lower than the UMAO coatings. When the BR content is 3.0 g/L, the self-corrosion current density of the UMAO/PLGA/BR coatings is the lowest (3.14 × 10−8 A/cm2) and the corrosion resistance is improved. UMAO/PLGA/BR coatings have excellent biological activity, which can effectively solve the clinical problem of rapid degradation of pure magnesium and easy infection.

Highlights

Traumatic bone repair materials have become a research hotspot in the field of orthopedics.They are mainly derived from autologous and allogeneic bone grafts [1]
The surface of the ultrasonic micro-arc oxidation (UMAO)/Polylactic acid glycolic acid copolymer (PLGA)/BR coatings was covered by PLGA/BR coating (Figure 1b–d)
The corrosion resistance of the UMAO coating was significantly improved by the coverage of PLGA/BR coatings with higher impedance and lower current significantly improved by the coverage of PLGA/BR coatings with higher impedance and lower density

Summary

Introduction

Traumatic bone repair materials have become a research hotspot in the field of orthopedics. They are mainly derived from autologous and allogeneic bone grafts [1]. The source of autologous bone grafting materials is limited, complications are prone to occur after surgery, and the success rate is low. Allogeneic bone graft materials are expensive and prone to rejection. The degradation of allogeneic bone is slow, resulting in a smaller volume of new bone. In order to solve the above problems, material researchers are trying to find suitable human bone repair materials. With the development of biodegradable materials, metal bone repair biomaterials are undergoing a revolution

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Results

Conclusion