Corrigendum

Abstract

CorrigendumCorrigendumPublished Online:01 Aug 2014https://doi.org/10.1152/ajpheart.H-zh4-1214-corr.2014Original articleMoreSectionsPDF (27 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInEmailWeChat Volume 302, February 1, 2012 Volume 71, February 1, 2012Pages H515–H526: Kristine M. Wadosky, Monte S. Willis. The story so far: post-translational regulation of peroxisome proliferator-activated receptors by ubiquitination and SUMOylation. Am J Physiol Heart Circ Physiol 302: H515–H526, 2012. First published October 28, 2011; doi: 10.1152/ajpheart.00703.2011.— On page H520, each time K107 is mentioned in reference to PPARγ1, it should read K77. Additionally, the “References” columns in Tables 1 and 2 contained incorrect reference numbers and have been corrected here.Table 1. Summary of ubiquitin and SUMO modification of PPARs and the resulting effects on transcription in the presence or absence of ligandNuclear ReceptorPost-Translational ModificationUbiquitin/SUMO Ligase (E3) IdentifiedModification TypeTranscriptional AffectEffect of LigandCell TypeReferencesPPARαUbiquitinationMDM2PolyubiquitinationMDM2-to-PPARα ratio < 0.5: Activation MDM2-to-PPARα ratio ≥ 1.0: InhibitionWy14643 is required for MDM2-dependent modulation of PPARα activityRat hepatoma(34)Inhibition of PPARα activity by promoting its degradationWy14643 blocks PPARα polyubiquitinationHepG2(10, 11, 40)SUMOylationPIASySUMO-1, K185Inhibition of PPARα activity by recruiting NCoR corepressorGW-7647 blocks PPARα monoSUMOylationCOS-7; human hepatoma(74)SUMO-2/3, K358Not determinedNot determinedNIH3T3; HepG2SUMO-1, K358Inhibition of PPARα activity by recruiting GA-binding protein and histone deacetylasesWY-14643 enhances PPARα monoSUMOylationNIH3T3; HepG2(75)PPARβ (also known as PPARδ)UbiquitinationNot determinedPolyubiquitinationInhibition of PPARβ activity by promoting its degradationPPARβ low and high: GW-501516, L-165041, and cPGI2 block PPARβ polyubiquitinationU2OS; human lung cell lines(30)PPARβ low: GW501516 does not affect PPARβ polyubiquitination PPAR high: GW-501516 blocks PPARβ polyubiquitinationHEK293; mouse fibroblasts(76)PPARγ1/2UbiquitinationNot determinedPolyubiquitinationInhibition of PPARγ1 activity by promoting its degradationThiazolidinediones enhance PPARγ polyubiquitinationDifferentiated adipocytes(38)SUMOylationPIAS1 & PIASxβ SUMOylates SENP2 deSUMOylatesSUMO-1, K77/K107 SUMO-1, K365/K395Inhibition of PPARγ1 activityRosiglitazone enhances PPARγ1 SUMOylationHEK293; HepG2; NIH3T3; vascular smooth muscle cells; in vivo rat cartiod artery; C2C12(14, 25, 56, 68, 72, 83, 97)Rosiglitazone has no affect on PPARγ1 deSUMOylation (C2C12)Inhibition of PPARγ1 activity by recruiting NCoR corepressorRosiglitazone enhances PPARγ1 SUMOylationMouse macrophageSee main text for definition of abbreviations.Table 2. Summary of ubiquitin and SUMO modification of PPAR coreceptor RXRα and coactivator PGC-1 α and the resulting effects on transcriptionPPAR Coreceptor/CoactivatorPost-Translational ModificationUbiquitin/SUMO Ligase (E3) IdentifiedModification TypeTranscriptional AffectEffect of LigandCell TypeReferencesRXRαUbiquitinationSmSINAPolyubiquitination targets Schistosoma mansoni RXR homologues (RXR1, RXR2) for degradationNot determinedNot determinedS. mansoni(22)RNF8 (E3 ligase?)RNF8 enhances RXRα activity independent of ubiquitinationCOS-7Not determinedPolyubitquitinationInhibition of RXRα by promoting its degradation9-cis-retinoic acid enhances RXRα polyubiquitinationSmooth muscle cells derived from human myometrium and leiomyomaSUMOylationSUSP1 (SENP6) SUMO protease (Removes SUMO)K108 SUMO-1SUSP1 deSUMOylation of RXRα enhances its activity.Not determinedHEK293(13)PGC-1αUbiquitinationNot determinedPoly-ubiquitination in nucleus(NH2-terminal pathway?)Inhibition of PGC-1α by promoting its degradation—COS-7 HL-1 (cardiac muscle cell line)(2, 82)SUMOylationPIAS1 and PIAS3 SUMOylates SUSP1 (SENP6) SUMO protease (Removes SUMO)K183 SUMO-1 K183 SUMO-1SUMOylation of K183 enhances PGC-1α activity—COS-1; HeLa(77)See main text for definition of abbreviations.This article has no references to display. Download PDF Previous Back to Top FiguresReferencesRelatedInformationRelated ArticlesThe story so far: post-translational regulation of peroxisome proliferator-activated receptors by ubiquitination and SUMOylation 01 Feb 2012American Journal of Physiology-Heart and Circulatory Physiology More from this issue > Volume 307Issue 3August 2014Pages H464-H466 Copyright & PermissionsCopyright © 2014 the American Physiological Societyhttps://doi.org/10.1152/ajpheart.H-zh4-1214-corr.2014History Published online 1 August 2014 Published in print 1 August 2014 Metrics