Corrigendum.

Abstract

ImmunologyVolume 156, Issue 2 p. 213-213 CorrigendumFree Access Corrigendum This article corrects the following: The T helper type 17/regulatory T cell paradigm in pregnancy Ana Sofia Figueiredo, Anne Schumacher, Volume 148Issue 1Immunology pages: 13-21 First Published online: April 4, 2016 First published: 26 November 2018 https://doi.org/10.1111/imm.13014AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat In1, errors have been identified in Fig. 1 image and figure caption. Figure 1Open in figure viewerPowerPoint Illustrative scheme of naive T cell differentiation into T helper type 1 (Th1), Th2, Th17 or regulatory T (Treg) cells, depending on the cytokine profile. Interleukin-12 (IL-12) and interferon-γ (IFN-γ) stimulated naive T cells differentiate to Th1 cells. These cells express IFN-γ and tumour necrosis factor-a (TNF-α), and are responsible for intracellular parasite clearance. IL-4 stimulated naive T cells induce a Th2 response. Th2 cells express IL-4, IL-5 and IL-13, and are responsible for clearance of extracellular parasites. Transforming growth factor-β (TGF-β) stimulated naive T cells induce a Treg response. Treg cells express TGF-β and IL-10 and are responsible for tolerance and pregnancy success. These three cell types express one cytokine responsible for its induction, in a positive feedback mechanism. TGF-β and IL-6 stimulated naive T cells induce a Th17 response. Th17 cells express IL-17, IL-21 and IL-22 and are responsible for autoimmunity and pregnancy loss. Th17 cells do not present a positive feedback mechanism, but IFN-γ or IL-4 can inhibit the differentiation from naive T cells to Th17. Moreover, IL-6 and IL-12 inhibit Treg and Th2 cells, respectively. The correct Fig. 1 is shown below. The authors apologize for the error and any confusion that it may have caused. Reference 1Figueiredo AS, Schumacher A. The T helper type 17/regulatory T cell paradigm in pregnancy. Immunology 2016; 148: 13– 21. Volume156, Issue2February 2019Pages 213-213 FiguresReferencesRelatedInformation