Abstract

The Authors regret that in the original abstract, Dr. Christie Orschell was listed as second author which was incorrect. The correct Author line is shown above. 3161 – CELLULAR AND MOLECULAR EFFECTS OF DMPGE₂ RADIOMITIGATION IN MOUSE AND HUMAN BONE MARROW CELLS IN VIVO USING C57BL/6 AND HUMANIZED NSG MOUSE MODELS OF ACUTE RADIATION SYNDROMEExperimental HematologyVol. 111PreviewThe hematopoietic system is highly sensitive to radiation exposure, and bone marrow (BM) failure from the hematopoietic acute radiation syndrome (H-ARS) is the primary threat to human life following a nuclear accident or attack. Dimethyl prostaglandin E2 (dmPGE₂) is a promising medical countermeasure (MCM) which significantly increases H-ARS survival in mice. Here mechanisms of dmPGE₂ radiomitigation were defined when given 24 h post-total body irradiation (TBI) in C57BL/6 mice and in humanized NOD scid gamma null (NSG) mice. Full-Text PDF

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