Abstract

Please tick as appropriate:Details of author(s) to be added to the manuscript (If the statement currently in the Manuscript/Proof is correct, please leave the below blank)AB and JF contributed equally to the writing of this article. AB, JF, CK, JK and JG designed this article. WK, GA, CK, and JG contributed to the article and provided critical remarks. KW and GAFN performed the structural analysis, JK analyzed the in vitro neutralization data for the landscape. AP and MMD contributed to the parts regarding the evolutionary pathway of pan-influenza protection. All authors contributed to the article and approved the submitted version.AB, JF, CK, JK, WK, GA, and JG have disclosed that they are employees of Leyden Laboratories with stock options in this company.The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Please provide the final authors list in the order they should appear in the final publicationNote that the final spelling and presentation of Author names (special characters, middle names, etc) will be as provided in the Manuscript/Proof. * By signing this form you agree a) for your name to added to/removed from the manuscript, b) to the new Author Contribution, Conflict of Interest and Acknowledgment statements and c) to the final author's list as listed in the form.

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