Abstract
Corrigendum: Cdk1 gates cell cycle-dependent tRNA synthesis by regulating RNA polymerase III activity.
Highlights
The cyclin dependent kinase Cdk1 is the master regulator of the cell cycle in Saccharomyces cerevisiae
Using ChIP-seq we have previously shown that Cdk1 localizes to at least 200 genes to promote their transcription during cell cycle progression [2]
Careful inspection of the data revealed that most of these ORFs were located in close proximity to tRNA genes or snoRNAs
Summary
The cyclin dependent kinase Cdk ( known as Cdc28) is the master regulator of the cell cycle in Saccharomyces cerevisiae. Cdk associates with nine different cyclins to execute the various stages of the cell cycle. Cdk is to activate cell cycle-dependent transcriptional programs by regulating the activity of various transcription factors [1]. We and others have shown that Cdk regulates the basal transcription machinery of RNA polymerase II (RNAP II) to stimulate the expression of many housekeeping genes upon cell cycle entry [2,3], which may be important for sustaining homeostasis as the cell forms a bud and expands its volume. In addition to Cdk, numerous other factors have been identified that affect cell cycle progression. Whereas regulation of tRNA synthesis under conditions of cell stress has been relatively well studied [7], exactly how tRNA synthesis is regulated in unperturbed, cycling cells is less well understood
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