Corrigendum: Aminoglycoside Conjugation for RNA Targeting: Antimicrobials and Beyond.

Abstract

The authors of this Review wish to correct some Figures and Schemes in which there were errors in the compounds’ configurations or structures. Specifically: Figures 1 and 2; Schemes 3, –10, 13, 24, and 25; Figures 19 and 20; as well as Schemes 35–37. A) Chemical structure of some natural and semisynthetic aminoglycoside antibiotics. B) Primary sequence and secondary structure of prokaryotic ribosomal A-site RNA, which is the target of aminoglycoside antibiotics. Chemical structures of arginine–aminoglycosides conjugates 1–4. Synthesis of 18–dipeptide conjugates 24. Synthesis of 18–PNA conjugate 45. DMAP: 4-dimethylaminopyridine, pyr: pyridine. Synthesis of 30–lysine–nucleoside conjugate 53. DCC: N,N′-dicyclohexylcarbodiimide, Tf2O; trifluoromethanesulfonic anhydride. Preparation of thymine–18 conjugate 60. TolSH: p-toluenethiol, HMDS: hexamethyldisilazane, NIS: N-iodosuccinimide. Synthesis of 18– and paromomycin–nucleobase conjugates 63 a–e and 66 a–e. Synthesis of oligonucleotide–18 conjugate 80. TFAA: trifluoroacetic anhydride, TBAF: tetra-n-butylammonium fluoride, DMTr: dimethoxytrityl. Preparation of chitosan–streptomycin conjugate 134. Synthesis of HA–AM conjugate 140. HATU: pyridinium-3-oxide hexafluorophosphate. Structures of homodimers of 30 with different linker types 191–193. Structures of disulfide-bridged neo–neo, tob–tob, and neo–tob conjugates 198–200. Synthesis of neamine dimers 209 a–c. TBTA: tris[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]amine. Preparation of 18–lipid conjugates 210. Synthesis of tobramycin–moxifloxacin conjugate 212. The corrected Figures and Schemes for the are given below. Additionally, the Frontispiece has also been corrected: The authors apologize for the oversight. The authors would like to thank Sébastien Vidal and Boris Vauzeilles for highlighting some of these errors.