Abstract
[This corrects the article DOI: 10.3389/fphys.2020.00386.].
Highlights
Conditional mouse mutant, I73T expression induced by Tamoxifen; Local and i.v application of clodronate
Summary of data from patients suffering fibrosis related to a SP-C mutation
Changes in BALF cells and lung mechanics are summarized for the available data
Summary
RSV infection, expression of SP-C inducible by doxycycline (on 129S6; 55.3/Sftpc-/-). Reduced stability of small bubbles but normal activity at standard bubble size Reduced health and fecundity. Higher mortality and weight loss, more pronounced fibrosis and delayed resolution. Preventive and therapeutic treatment with rapamycin failed to reduce bleomycin induced tissue inflammation and collagen deposition Reduced survival of 2-week-old mice, increased bacterial colony counts in 2-week-old 129S6 but not in FVB/N mice Higher susceptibility to RSV and delayed resolution of induced changes in lung morphology in both strains. SP-C expression reduced RSV-induced tissue inflammation and inflammatory cell counts and increased viral clearance More intense airway and airspace inflammation, delayed resolution of tissue inflammation. Delayed/arrested lung development and lethal neonatal respiratory distress syndrome
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