Abstract
I read with great interest the article by Polubuthu et al. reporting on the detection of PTPN11 mutations in several mosaic conditions, i.e. phacomatosis spilorosea, nevus spilus, nevus roseus and speckled lentiginous nevus syndrome (Polubuthu et al., [in press]). One of the paper’s conclusions is that mosaic PTPN11 mutations in nevus spilus predispose to cutaneous melanoma. I wish to challenge such conclusion based on the following points.
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