Correlative analysis of the level of serum cystatin-C in different severity of patients with stable chronic obstructive pulmonary disease

Abstract

Objective To observe change and the correlation of serum Cystatin C ( Cys-C) levels of the stability of stable chronic obstructive pulmonary disease (COPD) patients with different limited airflow and the severity of disease. Methods A total of 94 COPD patients of Shanxi Dayi hospital from January 2016 to December were followed up as COPD group; 31 healthy subjects in the hospital physical examination center were selected as healthy control group. Pulmonary function tests, serum cystatin C and creatinine (Cr) levels were measured respectively, meanwhile, Calculated glomerular filtration rate. According to the estimated percentage of pulmonary function FEV1, the patients with COPD were divided into four different subgroups: GOLD1, 2, 3 and 4stage; According to the history of acute exacerbation number and COPD assessment test, the patients with COPD were divided into four different subgroups: A, B, C and D. Results The serum Cys-C level in patients with stable COPD was higher than those in healthy controls (P<0.05). There were significant differences in the serum Cys-C among stable COPD patients of GOLD1, 2, 3 and 4stage(P<0.01), the serum Cys-C levels in GOLD4 stage were higher than GOLD1, 2, 3 stage.There were significant differences in the serum Cys-C among stable COPD patients of A, B, C and D subgroup(P<0.01), the serum Cys-C levels in D subgroup were higher than A, B subgroup, the serum Cys-C levels in C subgroup were higher than A subgroup. The serum Cys-C levels were positive correlated with CRP (P<0.01) and significantly negative correlated with FEV1(P<0.01) and GFR(P<0.01). Conclusions COPD patients serum Cys-C level is higher, and increased with COPD disease severity. The serum Cys-C level may become biomarkers of the assessment of severity in patients with COPD. Key words: Chronic obstructive pulmonary disease; Cystatin-C; Lung function