Correlative analysis of serum high sensitivity C-reactive protein and white blood cell count with coronary lesion and risk factors

Abstract

Objective To investigate the relationship of high-sensitivity C-reactive protein (hsCRP) and white blood cell count (WBC) with extent of coronary lesion and if it is an independent risk factor for coronary heart disease (CHD).Methods One hundred and twelve patients with CHD confirmed by angiography and 35 patients without CHD (excluded by coronarography).All patients measuring WBC,serum hs-CRP,serum high density lipoprotein (HDL-C),low density lipoprotein (LDL-C),and 2 h postprandial blood glucose levels by automated hematology analyzer (AHA) and latex immune enhancement act.According to the results of coronary angiography,CHD group was divided into 1,2,3 lesions,observed the relationship between WBC and hs-CRP with coronary artery lesions.Also investigated age,gender,body mass index (BMI),blood pressure,smoking.Results There were significantlydifference (P ＜ 0.01) between two groups in WBC,serum of hs-CRP,HDL-C,LDL-C,postprandial 2 h blood glucose levels.With the increase in the number of coronary arteries,the WBC count,serum hs-CRP levels gradually increased.White blood cell count and body mass index,waist circumference,blood pressure,HDL-C and LDL-C,2-hour postprandial blood glucose were positively correlated (P ＜ 0.01),they were negatively correlated with high density lipoprotein (P =0.000).White blood cell count and severity of coronary lesions were positively correlated (r =0.400,P =0.000).The level of white blood cell count as the dependent variable multiple regression analysis showed that the only variable,BMI,of hs-CRP,smoking into the regression equation.Conclusions Inflammatory response may be involved in the occurrence of coronary artery disease,white blood cell count levels are related with cardiovascular disease risk factors such as obesity,2 h postprandial blood glucose,blood pressure,LDL and smoking. Key words: White blood cell count; C-reactive; Coronary heart disease