Abstract
BackgroundThis study aims to investigate the correlations of asthma in children with body mass index (BMI), adiponectin, and leptin.MethodsA total of 122 children with asthma in our hospital from January 2017 to February 2018 were randomly selected and divided into control group (normal) and observation group (BMI > 28 kg/m2) according to BMI. BMI, adiponectin, and leptin levels between the two groups were measured and compared, and correlations of disease grade with BMI, adiponectin, or leptin were analyzed. Moreover, risk factors for asthma in children were also identified.ResultsBody mass index, leptin level, forced vital capacity (FVC), FVC%, and forced expiratory volume in 1s (FEV1)/FVC in observation group were significantly higher than those in control group (P < 0.05), while the adiponectin level, forced expiratory capacity in 1s (FEC1), and FEV1% in observation group were significantly lower than those in control group (P < 0.05). The amount of severe patients in observation group was much larger than that in control group. The severity of disease was positively correlated with BMI and leptin and negatively correlated with adiponectin. BMI, adiponectin, and leptin were identified as risk factors for asthma in children.ConclusionAdiponectin, leptin, and BMI are involved in the pathogenesis of asthma in children, suggesting they might be therapeutic targets for clinical treatment.
Highlights
Asthma in children is generally found with a high prevalence rate, the incidence rate of which, according to statistical analy‐ sis, increases year by year with the environmental changes
Adipocytes in the body can pro‐ duce adipokines, adiponectin, and leptin, which may be related to the pathogenesis of asthma.[10,11]
To investigate the pathogen‐ esis of asthma in children, the correlations of asthma in children with body mass index (BMI), adiponectin, and leptin were mainly investigated in this study
Summary
Asthma in children is generally found with a high prevalence rate, the incidence rate of which, according to statistical analy‐ sis, increases year by year with the environmental changes. There have been few clinical studies on asthma in children, and its pathogenesis remains poorly understood.[4-6]. The body mass index (BMI) of patients is considered as an important indicator to the severity of the disease.[7-9]. Adipocytes in the body can pro‐ duce adipokines, adiponectin, and leptin, which may be related to the pathogenesis of asthma.[10,11]. This study aims to investigate the correlations of asthma in children with body mass index (BMI), adiponectin, and leptin. Risk factors for asthma in children were identified. BMI, adi‐ ponectin, and leptin were identified as risk factors for asthma in children. Conclusion: Adiponectin, leptin, and BMI are involved in the pathogenesis of asthma in children, suggesting they might be therapeutic targets for clinical treatment
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