Abstract
The correlations of reduced glutathione (GSH) and glutathione peroxidase (GPx) levels with biochemical markers of liver and kidney damage in Trypanosoma brucei brucei infection were studied in rats. Forty adult male rats divided into 2 groups of control and infected were used. Infected rats were inoculated intraperitoneally with 1.0 ml of blood at concentration of 1 x 106 trypanosomes per ml. Serum and tissue samples were collected on days 0, 3, 5 and 7 post-infection (pi) for biochemical analyses. Serum GPx activity had a significant (p < 0.05) positive correlations with liver (r = 0.96) and kidney GSH (r = 0.93) levels. All the measured serum parameters had significant (p < 0.05) negative correlations with serum GPx activity. In conclusion infection of rats with T. brucei brucei caused a decrease in the serum GPx activities and organ GSH levels with increasing parasitaemia and duration of the infection.
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