Correlations of levels of glycosylated hemoglobin and lipoprotein (a) with severity of neurological impairment in stroke patients when being admitted

Abstract

Objective To investigate the correlations of the levels of glycosylated hemoglobin (HbA1c) and lipoprotein (a) [LP (a)] with the severity of neurological impairment in stroke patients when being admitted. Methods 120 stroke patients treated at our hospital from April, 2014 to March, 2016 were selected as study objects. According to the score of 24 h National Institutes of Health Stroke Scale (NIHSS), the objects were divided into a mild stroke group (NIHSS score 15 points), 40 cases for each group. The HbA1c, LP (a), cerebral infarction diameter, NIHSS score, and the modified Rankin scale (MRS) score were compared between the 3 groups, and the correlations of the levels of HbA1c and LP (a) with NIHSS score, cerebral infarction diameter, and MRS score were analyzed. Results The HbA1c, LP (a), cerebral infarction diameter, NIHSS score, and MRS scores in the severe stroke group were the highest, followed by those in the moderate stroke group and the mild stroke group (all P<0.05). Correlation analysis showed that the levels of HbA1c and LP (a) positively correlated with NIHSS score, cerebral infarction diameter, and MRS score in stroke patients (r = 0.865, 0.743, and 0.725 and 0.842, 0.816, and 0.736, all P<0.05). Conclusions HbA1c and LP (a) levels closely relate to the severity of neurological impairment in stroke patients. The more serious neurological impairment and cerebral infarction are, the higher the HbA1c and LP (a) levels are. They can be used as early warning factors of stroke. Key words: Glycosylated hemoglobin; Lipoprotein (a); Stroke; Neurological function; Relationship