Correlations of insulin-like growth factor-1 and insulin resistance with lower urinary tract symptoms in elderly male patients

Abstract

Objective To investigate the correlations of serum insulin-like growth factor-1 (IGF-I) and insulin resistance with lower urinary tract symptoms (LUTS) in elderly male patients. Methods 96 old-elderly patients with benign prostatic hyperplasia (BPH) were divided into two groups according to international prostate symptoms score (IPSS) and abdominal ultrasound- measured prostate volume: experimental group(n=54, patients with obvious LUTS and IPSS score- assessed severe symptoms) and control group(n=42, patients without obvious LUTS and slight symptoms assessed by IPSS scores). Clinical data and biochemical characteristics were compared between the two groups. The correlations between the indicators were analyzed. Results There were significant differences in levels of fasting blood glucose and fasting serum insulin, homeostasis model assessment-insulin resistance, low-density lipoprotein level, prostate volume between experimental and control groups 〔(6.3±0.7) mmol/L vs. (4.9±0.5) mmol/L, (11.9±3.1) mU/L vs. (8.0±2.0) mU/L, (3.5±1.3) vs. (1.8±0.5), (3.9±0.3) mmol/L vs. (2.2±0.4) mmol/L and (38.9±6.4) ml vs. (23.2±1.3) ml, all P<0.05, respectively〕. Serum levels of IGF-I and high-density lipoprotein cholesterol were lower in experimental than in control group 〔(114.6±25.6) μg/L vs. (165.3±48.6) μg/L〕 and (1.1±0.3) mmol/L vs. (1.9±0.2) mmol/L, both P<0.01, respectively〕. The serum IGF-I level was negatively correlated with age, levels of fasting blood glucose, and fasting serum insulin, homeostasis model assessment - insulin resistance and low-density lipoprotein level (all P<0.05). The prostate volume was positively correlated with age, levels of fasting blood glucose, fasting serum insulin, and homeostasis model assessment - insulin resistance (all P<0.05), while negatively correlated with high-density lipoprotein cholesterol level (P<0.01). Conclusions The level of serum IGF-I and insulin resistance have a relation with BPH severity and might participate in the development of BPH. Key words: Insulin-like growth factor-1; Prostatic hyperplasia; Dysuria