Correlations of frontal resting-state EEG markers with MMSE scores in patients with Alzheimer\u2019s disease

Abstract

BackgroundA previous study suggests that resting-state EEG biomarkers measured at prefrontal region (Fp1, and Fp2) are moderately correlated with Mini-Mental State Examination (MMSE) scores of elderly people with Alzheimer’s disease. In this study, our objective was to investigate whether resting-state EEG biomarkers recorded from frontal region are correlated with each MMSE sub-scores. 20 elderly patients diagnosed as Alzheimer’s disease entered to the study. After completion of MMSE, subjects underwent EEG for 5 min with closed eyes condition. We measured median frequency, theta/alpha power ratio, and relative powers. To examine the relationship between these features and MMSE sub-scores first, Pearson correlation coefficients were computed for each feature and MMSE sub-scores. Then, p values were computed for each correlation. Finally, a Bonferroni correction was done.ResultsNine correlations have been found for markers recorded from F3, F7, and Fz. Alpha and beta relative powers were the markers which shows correlations. We found that MMSE overall, attention, and calculation scores are significantly correlated with beta relative powers recorded from F3, and Fz, and alpha relative power from F7. Orientation to time scores were correlated with F3, and Fz beta relative powers. The only correlation found for orientation to place was beta relative power of F3.ConclusionsOur results indicate that there are correlations between frontal EEG markers and MMSE sub-scores of patients with Alzheimer’s disease. The results show that alpha and beta relative powers are markers correlated with MMSE scores. It seems that if we want to develop predicting models for Alzheimer’s disease, using data recorded from other frontal electrodes, especially what we have introduced should be considered.