CORRELATIONS OF ENDOGENOUS TESTOSTERONE AND DHEA-S IN PERIPHERAL ARTERIAL DISEASE

Abstract

Background: Peripheral arterial disease is Occlusive disease of the arteries of the extremity. Common causes are Atherosclerosis (most common), Buerger's disease, vasculitis and other arteritis, thromboembolism etc. Peripheral arterial disease (PAD) is a treacherous disease as it remains asymptomatic for so long. As PAD progresses, it may lead to classical intermittent claudication and critical limb ischemia. DHEAS has been demonstrated to have an antiatherosclerotic effect by prevention of platelet aggregation, uptake of cholesterol and a decrease in the proliferation of vascular smooth muscle cells. Testosterone causes vasodilation of the peripheral arteries by acting on the endothelium of the vessels and in turn results in release of nitric oxide (NO) which is a vasodilator and helps in vasodilation. Testosterone suppresses expression of vascular cell adhesion molecule-1 (proinammatory cytokines), anti-inammatory factors by its derivative 5-dihydrotestosterone which is the earliest step in atherosclerosis. Interestingly Testosterone and DHEAS also has benecial effects on cardiac ischemia, angina and chronic heart failure. The aim of this study is to look for any relationship of Testosterone and DHEAS in Peripheral Arterial Disease. Total 50 patients both inpatients and out Methods: patients were studied. The period of study was from September 2016 to June 2018. Patients who were proven to have peripheral arterial disease on colour doppler were taken for study. The study was done to look if any relationship is present between serum testosterone and dehydroepiandrosterone sulfate (DHEA-S) in a peripheral arterial disease patients. Data were documented and stored in a proper database format. At the end of data collection from the samples, data analysis was done using SPSS 16 software and appropriate tests of signicance were applied. For categorical variables Chi-square test and Fischer's Exact test was used. For comparing two groups of mean student's t-test was used. To correlate more than two continuous data Pearson and Spearman Correlation Coefcient was used. P value <0.05 considered as statistically signicant. Our results showed that total serum testosterone Results: and DHEA-S were not signicantly decreased in PAD patients in comparison to the control group. We could not observe any signicant correlation. These results express that there is no signicant correlation Conclusion: of Serum Testosterone and Dehydroepiandosterone with Peripheral arterial Disease. In our study there are signicant correlations with inammatory markers (C reactive protein, Interleukin6, Homocysteine) Lipid prole (cholesterol, Triglyceride, HDL, VLDL) and HbA1C with serum Testosterone and Dehydroepiandosterone in Peripheral Arterial Disease