Abstract
Detection of principal subclinical arterial wall lesions is one of the most important aspects of effective cardiovascular disease (CVD) primary prevention. Such lesions include: arterial wall thickening, increased rigidity, endothelial dysfunction development. However, the role of traditional CVD risk factors in the development of individual arterial wall lesions in CVD-free people is understudied. This is particularly so with people of older age. Aim. To study the role of traditional CVD risk factors in development of arterial wall lesions in relatively healthy individuals of different age. Material and methods. We have examined a total of 303 people aged 25-91 years, with no signs of CVD and other chronic diseases and without any regular medical treatment. Anthropometric parameters, blood pressure, fasting plasma glucose, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides levels were detected in all the patients. Measurement of pulse wave velocity was conducted using SphygmoCor device (AtCorMedical,Australia). Carotid ultrasound to measure intima-media thickness and number of atherosclerotic plaques was conducted using linear transducer with ultra-high resolution 17-5 MHz (PHILIPS iU22, the Netherlands) in the B-mode. Endothelium-dependent vasodilation was assessed by the reactive hyperemia test. Results. Multivariate linear regression analysis has revealed fasting hyperglycemia and increased systolic blood pressure to be to a greater degree associated with arterial wall state in both age groups. According to the results of multivariate logistic regression analysis a relationship between risk factors and arterial wall parameters is stronger in the younger group as compared with the older one. Conclusion. Systolic blood pressure and fasting hyperglycemia must be the main targets of CVD primary prevention in older age group, while in younger age group other traditional risk factors must be taken into account as well.
Highlights
Detection of principal subclinical arterial wall lesions is one of the most important aspects of effective cardiovascular disease (CVD) primary prevention
Systolic blood pressure and fasting hyperglycemia must be the main targets of CVD primary prevention in older age group, while in younger age group other traditional risk factors must be taken into account as well
As age is the most important factor determining the risk for onset, course of a CVD and its prognosis, we have supposed that the presence and specifics of relationships between traditional risk factors (RF) and arterial wall parameters differ in younger and older ages
Summary
Detection of principal subclinical arterial wall lesions is one of the most important aspects of effective cardiovascular disease (CVD) primary prevention. The role of traditional CVD risk factors in the development of individual arterial wall lesions in CVD-free people is understudied This is so with people of older age. Correlations between parameters of arterial wall and cardiovascular risk factors Взаимосвязь параметров артериальной стенки и факторов сердечно-сосудистого риска. Akasheva – MD, PhD, Leading Researcher of the of the Department of Investigation of Ageing and Age-associated Diseases Prevention, SRC PM Ekaterina N. Отдела изучения процессов старения и профилактики возраст-ассоциированных заболеваний ГНИЦ ПМ Ткачева Ольга Николаевна – д.м.н., профессор, руководитель того же отдела, директор РГНКЦ РНИМУ им. Пирогова Исайкина Олеся Юрьевна – к.м.н., с.н.с. отдела первичной профилактики хронических неинфекционных заболеваний в системе здравоохранения ГНИЦ ПМ Выгодин Владимир Анатольевич – с.н.с. лаборатории биостатистики ГНИЦ ПМ Бойцов Сергей Анатольевич – д.м.н., профессор, руководитель отдела кардиологии и молекулярной генетики, директор ГНИЦ ПМ
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