CORRELATIONS OF BODY MASS INDEX WITH CLINICAL AND LABORATORY INDICATORS IN PATIENTS WITH ESSENTIAL ARTERIAL HYPERTENSION DEPENDING ON AGT (RS699) GENE POLYMORPHISM

Abstract

The aim. To analyze the correlations between body mass index (BMI) and clinical and laboratory parameters in patients with essential hypertension (EAH) depending on AGT gene (rs699) polymorphism. Materials and methods. The case-control study involved 72 patients with stage II EAH, 1–3 degrees of blood pressure (BP), high and very high cardiovascular risk (CVD) (29.16% (21) men, 70.84% ​​(51) women). The mean age of patients was 59.87 ± 7.98 y.o. The control group consisted of 48 healthy individuals comparable in age and gender. Polymorphism of the AGT gene (rs699) was detected by polymerase chain reaction. BMI was defined as the ratio of weight to square of height (kg/m2). Results. The correlation matrix showed a direct relationship between BMI and anthropometric parameters of waist circumference (WC), hip circumference (HC) and WC/HC ratio (r = 0.70–0.81; p ≤ 0.022), vitamin D level (r = 0,65; p = 0.043) and the reverse with the level of ionized Ca2+ in the blood (r = -0.71; p = 0.02) among TT-genotype carriers; in TC-genotype carriers BMI was directly related to WC and HC (r = 0.68; p < 0.001 and r = 0.84; p < 0.001), as well as the level of parathyroid hormone (PTH) (r = 0,43; p = 0.004), with a negative correlation with the level of vitamin D (r = -0.38; p = 0.011); in CC-genotype carriers, a direct link was found between BMI and WC and HC (r = 0.73; p < 0.001 and r = 0.78; p < 0.001). Conclusions. Thus, the correlation matrix showed that BMI directly depended on the anthropometric parameters of WC, HC and/or WC/HC (r = 0.68-0.84; p ≤ 0.022-0.001) regardless of the AGT gene genotypes (r = 0,52-0.86; p ≤ 0.02-0.001) and inversely correlated with the ionized Ca2+ level in the blood (r = -0.71; p = 0.02), but only in TT-genotype carriers of the AGT gene (rs699).