Correlations of Body Mass Index, Japan-Defined and IDF-Defined Waist Circumference, Visceral and Subcutaneous Fat Area with Metabolic Parameters in Japanese Patients with Type 2 Diabetes

Hidekatsu Yanai,Yuji Hirowatari

doi:10.4236/jdm.2015.54036

Abstract

Obesity is included in the definition of metabolic syndrome. However, there are many controversies surrounding the evaluation of obesity such as body mass index (BMI) and waist circumference (WC) in the definition of metabolic syndrome among various populations. To understand precisely how various anthropometric indices of obesity influence metabolic parameters, we studied the correlations of BMI, WC (Japanese criteria), WC (IDF criteria), visceral fat area (VFA), subcutaneous fat area (SFA) and the VFA/SFA ratio with metabolic parameters in patients with type 2 diabetes. The influences of BMI and WC on diastolic blood pressure and HDL-cholesterol were larger than VFA, whereas the influences of visceral fat area on triglyceride, very low-density lipoprotein-cholesterol, C-peptide and high-sensitivity C-reactive protein were larger than BMI and WC. WC (IDF) was the strongest determinant of adiponectin among anthropometric indices. Present study showed significant different associations of BMI, Japan- and IDF-defined WC, VFA, SFA and the VFA/SFA ratio with blood pressure, glucose and lipid metabolism, and adipocytokines in Japanese patients with type 2 diabetes.

Highlights

Obesity, which is included in the definition of metabolic syndrome, has been considered to be a major risk factor for atherosclerosis [1]
To understand precisely how various anthropometric indices of obesity influenced metabolic parameters, we studied the correlations of body mass index (BMI), waist circumference (WC) (Japanese criteria), WC (IDF criteria), visceral fat area (VFA), subcutaneous fat area (SFA) and the VFA/SFA ratio with blood pressure, glucose and lipid metabolism, adipocytokines, albuminuria in patients with type 2 diabetes
BMI, WC (Japanese and International Diabetes Federation (IDF) criteria) were significantly and positively correlated with diastolic blood pressure (BP), VFA, SFA and the VFA/SFA ratio were not correlated with diastolic BP (Table 1)

Summary

Introduction

Obesity, which is included in the definition of metabolic syndrome, has been considered to be a major risk factor for atherosclerosis [1]. There are many controversies surrounding the evaluation of obesity such as body mass index (BMI) and waist circumference (WC) in the definition of metabolic syndrome among various populations [2]. We studied the association of BMI and visceral fat area (VFA) with metabolic parameters in Japanese patients with type 2 diabetes, and found significant different associations of BMI and VFA with metabolic parameters [6]. To understand precisely how various anthropometric indices of obesity influenced metabolic parameters, we studied the correlations of BMI, WC (Japanese criteria), WC (IDF criteria), VFA, subcutaneous fat area (SFA) and the VFA/SFA ratio with blood pressure, glucose and lipid metabolism, adipocytokines, albuminuria in patients with type 2 diabetes

Methods

Results

Conclusion