Correlations of biochemical parameters of blood serum in swine during anti-parasitic treatment with Ivermin followed by pharmacocorrection

Abstract

The control of endo- and ectoparasites of animals takes an important place in the complex of medical and preventive measures carried out on farms and livestock enterprises of industrial type. Considering the risk of adverse effects of anti-parasitic drugs, we analyzed the changes of biochemical parameters of blood serum in swine (commercial hybrid) with a single subcutaneous injection of Ivermin (A.D. Ivermectin) at a dose of 0.2 mg/kg with subsequent introduction of a double Azoxivet immunostimulator (A.D. Azoximer bromide) in a dose of 0.5 mg/kg and the carbon enterosorbent Zoocarb at a dose of 0.2 g/kg 2 times a day for 3 days. In 14 days after the start of the experiment, biochemical analysis of blood serum was performed using the Screen Master Analyzer and a set of reagents from the company “Human” (Germany). Statistical data processing was performed using the Student’s parametric T-Test for independent samples. The correlations between variables were evaluated using Spearman’s Rank Correlation Coefficient. It turns out that Ivermin, when administered in a single therapeutic dose causes changes in the biochemical parameters of blood serum, indicating a high risk of hepatotoxic and nephrotoxic effects. The number of correlations of symptoms with the introduction of Ivermin increases. Pharmacocorrection allows minimizing the marked changes. Statistically significant correlations of variables disappear, and this indicates a decrease in adaptive stress.