CORRELATIONS BETWEEN URIC ACID SERUM LEVEL AND LEFT VENTRICULAR HYPERTROPHY IN PATIENTS WITH HYPERTENSION AND CHRONIC KIDNEY DISEASE: PP.27.78

Abstract

Background: Several studies on the general population have suggested an association between uric acid level and cardiovascular outcomes. Other studies also have shown an association of uric acid level with established cardiovascular risk factors as hypertension and diabetes. Hyperuricemia is highly prevalent in patients with chronic kidney disease (CKD). Objective: The evaluation of correlation between serum uric acid level and left ventricular hypertrophy in patients with essential hypertension and chronic kidney disease Material and Methods: 57 patients with stage III of essential hypertension and chronic kidney disease were studied. All patients were examined for serum uric acid concentration. Patients were divided in 2 groups based on the presence of hyperuricemia, defined as serum uric acid level greater than 9 mg/dL or lower than 8 mg/dL. Left ventricular abnormalities have been determined by bidimensional echocardiography. The left ventricular mass index (LVMI) has been evaluated according to the method of Devereux and Reichek Results: A positive correlation was observed between uric acid level (UA) and LVMI. (r = 0.412, p < 0, 05). The study evidenced that patients, which presented uric acid levels > 9 mg /dl show significant differences in left ventricular hypertrophy degree and systolic left ventricular functions compared with patients which presented uric acid levels < 8 mg/dl Conclusions: The results show that elevated UA serum levels are associated with left ventricular hypertrophy and worsening of systolic left ventricular function in patients presenting chronic hypertensive disease and CKD.