Correlations between retinal nerve fiber layer measurements obtained with the GDx VCC and standard automated perimetry

Abstract

Abstract Purpose: To correlate the structural parameters of the retinal nerve fiber layer (RNFL) obtained by using the scanning laser polarimetry with variable corneal compensation (GDx‐VCC) and the results of automated perimetry (SAP), in normal, ocular hypertensive, preperimetric glaucomas and glaucoma subjects. Methods: 423 eyes of 423 consecutive subjects were prospectively included in the study and classified depending on baseline intraocular pressure, optic nerve head appearance and SAP results into four groups: 87 normal eyes, 192 ocular hypertensive eyes, 70 preperimetric glaucomas and 74 glaucomatous eyes. In the different diagnostic groups, Pearson`s correlations were calculated between mean deviation (MD), pattern standard deviation, and the fifty two threshold points of SAP and structural parameters of RNFL obtained with the GDx VCC. Regression`s curves for the strongest correlations were also calculated. Results: Mild or no significant correlations were found in the normal, ocular hypertensive and preperimetric glaucoma groups. Nevertheless, the glaucoma group presented mild to moderate correlations between several GDx VCC parameters and the analyzed SAP variables. The strongest correlations were observed between the standard deviation TSNIT and the MD (0.460) and between superior average with the threshold point number 45 (0,496). Conclusions: RNFL parameters measured with the GDx VCC presented mild to moderate correlations with the visual field indices and the threshold values of SAP in the glaucoma group.