Correlations between plasma adiponectin and markers of oxidative stress in coronary artery disease and its equivalents

Abstract

with coronary heart disease (CHD) with multiple tissue Doppler imaging(TDI) parameters in rest state and to discuss the value of regional cardiac function in diagnosing CHD. Design and methods: Forty-seven inpatients with chief complaint of chest pain underwent TDI examination. Maximum systolic velocity (Sm), maximum early diastolic velocity (Em), maximum late diastolic velocity (Am), isovoluminal contraction time (IVCT) and isovoluminal relaxation time (IVRT) of sixteen segments of left ventricle were measured. All the patients underwent coronary angiography (CAG) at the same time. CHD was diagnosed by at least one coronary artery with no less than 50% diametric stenosis. Segments dominated by coronary artery with 50 to 90 and more than 90% diametric stenosis were moderate and severe lesion segments respectively. Others were non-lesion segments. Results: No obvious influences were observed in left ventricular ejection fraction (LVEF) and E/A ratio in different coronary lesions. Compared with non-lesion segments, velocity parameters Sm, Em and Em/Am of lesion segments decreased, and time parameters IVCT and IVRT prolonged. If setting a criterion that no less than three segments with Sm − 2.50 cm/s and IVRT>87 ms for CHD diagnosis, the sensitivity, specificity, positive predictive value and negative predictive value were 79.4%, 84.6%, 93.1% and 61.1%. Conclusions: In rest state, regional cardiac function of lesion segments in CHD patients showed changes of decreased systolic and diastolic velocities and prolonged isovoluminal time. Analysing segmental cardiac velocity and time comprehensively may help diagnose CHD.