Correlations between parameters in pressure-flow analysis and histological compositions in prostate in patients with benign prostatic hyperplasia.

Abstract

To investigate whether the differences in histological composition would be responsible for the grade of bladder outlet obstruction evaluated by pressure-flow (P-F) study and that increase in some histological components would result in increased degree of the obstruction, we evaluated relationships between morphometic data and results of P-F study. All prostate specimens with benign prostatic hyperplasia (BPH), obtained from 18 patients undergoing transurethral resection of the prostate, were analyzed by quantitative morphometry. Preoperatively each patient underwent P-F study. Stroma comprised the greater part of prostate (73%). Of all histological elements, fibrous tissue was the largest (48%). The relative and total volume of respective components showed no correlationships with parameters in P-F study. The differences in tissue composition did not affect the outcome of urodynamics. This result was the same even in a smooth muscle-rich subgroup. Also, in view of how small or large fibrous tissue and glandular elements were, no significant correlationships could be pointed out. The degree of infravesical obstruction and the outcome of P-F study cannot be explained by histological composition alone.