Abstract
Background The noninvasive assessment of liver fibrosis in chronic hepatitis C patients is very important as it dictates the disease prognosis and the indication for therapy, narrowing down the use of the liver biopsy. Standardized scores (FibroTest, FibroMax) and imaging techniques (FibroScan) have been validated in this respect. As for the noninvasive prediction of the sustained viral response (SVR), GenoFibroTest and Prometheus are two indexes that may be used. This study’s aim is to compare several biological scores with these standardized scores for evaluating fibrosis and the two indexes for prediction of SVR.
Highlights
The noninvasive assessment of liver fibrosis in chronic hepatitis C patients is very important as it dictates the disease prognosis and the indication for therapy, narrowing down the use of the liver biopsy
We performed a cross-sectional analysis on a group of patients with chronic hepatitis C evaluated at the National Institute for Infectious Diseases “Prof. Dr Matei Balş”
The median FibroTest values were 0.55±0.30 while the median FibroScan scores were 8.8±9.7 kPa
Summary
The noninvasive assessment of liver fibrosis in chronic hepatitis C patients is very important as it dictates the disease prognosis and the indication for therapy, narrowing down the use of the liver biopsy. Standardized scores (FibroTest, FibroMax) and imaging techniques (FibroScan) have been validated in this respect. As for the noninvasive prediction of the sustained viral response (SVR), GenoFibroTest and Prometheus are two indexes that may be used. This study’s aim is to compare several biological scores with these standardized scores for evaluating fibrosis and the two indexes for prediction of SVR
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