Abstract
The objective of this study was to assess the correlations of amylin (a pancreatic polypeptide hormone) with some hormonal, biochemical and bone parameters in pullets. Forty 18-week-old pullets were used. Plasma amylin, CT (calcitonin), 1,25 (OH)2 vitamin D (1,25 dihydroxycholecalciferol ), serum osteocalcin, glucose, ALP (alkaline phosphatase), cholesterol, and triglycerides, as well as weight, length and total volume of tibiotarsi were measured. Plasma amylin concentration was negatively correlated with serum cholesterol (p<0.05) and triglycerides (p<0.05) concentrations. Plasma amylin concentration was significantly and positively correlated with plasma calcitonin concentrations (p<0.001). Serum ALP and plasma amylin concentrations were positively correlated (p<0.01). There were no correlations between amylin hormone and other parameters. Based on these results, it is possible to conclude that endogen amylin may effect cholesterol, triglycerides, calcitonin, and ALP levels in pullets without changing some other hormonal, biochemical and bone parameters related to calcium and lipid metabolism.
Highlights
Amylin is a hormone composed of a 37-amino acid peptide and was discovered in 1987 (Cornish et al, 1998a)
Northernblot analysis indicates that IAPP mRNA is expressed in the chicken brain and intestine at a greater than 10 fold higher level than that found in the pancreas (Westermark et al, 2011)
Receptors for amylin are highly concentrated especially in the central nervous system, area postrema and nucleus accumbens, but it is likely that they are present on the surface of osteoblasts and osteoclasts as well (Fu et al, 2013)
Summary
Amylin is a hormone composed of a 37-amino acid peptide and was discovered in 1987 (Cornish et al, 1998a). Known IAPP (islet amyloid polypeptide), is colocalized with insulin in the beta-cells of the pancreatic islets (Lebovitz, 2010). It is found in much lesser quantities in the gastrointestinal tract and hypothalamus. Amylin and CGRP have been reported to have CT-like hypocalcemic activity in vivo. Both human amylin and CGRP inhibited 1,25 (OH) vitamin D (1,25 dihydroxycholecalciferol)-induced bone resorption in a tissue culture system, and the biological potencies of the two peptides were approximately 60-fold lower than that recorded for human CT
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