Abstract
Concentrations of cytochrome P450 (CYP), activities of aryl hydrocarbon hydroxylase (AHH), haem synthetase (HEM-S), and 5-aminolevulinic acid synthetase (ALA-S) in liver as well as fluorescent aromatic compounds (FACs) in bile of flounder (Platichthys flesus) were studied in samples collected during a synoptic survey along a transect in the Baltic in autumn 1994. Cytochrome P450 concentrations and activities of the haem synthesis enzymes HEM-S and ALA-S were highest in the northwestern areas and among these parameters significant (p<0.01) positive correlations were found. Highest activities of microsomal AHH were measured in flounder from areas near major ports in the centre of the transect. Concentrations of FACs in bile correlated significantly with AHH activities. The results indicate that CYP concentrations and ALA-S and HEM-S activities, which are generally considered the principal biomarkers of carcinogenic pollution, may give a different perspective on carcinogenesis in fish.
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