Correlations between chronic venous leg ulcer and matrix metalloproteinases

Abstract

Chronic venous leg ulcer (CVLU) is a common and refractory complication of chronic venous diseases, and is clinically characterized by chronic leg ulcers and pain. Matrix metalloproteinases (MMPs) are a kind of highly conservative and zinc-dependent endopeptidases, and can be divided into 6 types according to their substrates and structures. Among the 6 types, collagenases, gelatinases and stromelysins play a key role in the occurrence and development of CVLU. Moreover, the up-regulation of MMP-1,-2,-3,-8 and ratio of MMP-2 to tissue inhibitor of metalloproteinase-2 (TIMP-2) is associated with delayed ulcer healing, whereas the up-regulation of MMP-7,-10,-13 and TIMP-1,-2 facilitates ulcer healing. However, roles of MMP-9 and -12 in venous ulcers are still unclear and need further study. According to functional characteristics of some MMPs, intervention of their composition and functions may provide new therapeutic targets for the treatment of CVLU. Key words: Varicose ulcer; Lower extremity; Matrix metalloproteinases; Extracellular matrix; Wound healing