Abstract
BackgroundIt is widely acknowledged that nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus(T2DM) are all chronic metabolic diseases. The objective of this study is to retrospectively probe the association between the 25-hydroxyvitamin D (25-(OH)D) and NAFLD in type 2 diabetic patients.MethodsThree hundred thirty-nine T2DM patients participated in this research and from November 2018 to September 2019 and were divided into simple T2DM group (108 cases) and T2DM with NAFLD group (231 cases) in conformity with abdominal ultrasound diagnosis. The NAFLD fibrosis score (NFS) ≥0.676 was defined as progressive liver fibrosis.231 T2DM with NAFLD patients were categorized into two subgroups: progressive liver fibrosis subgroup (48 cases) and without progressive liver fibrosis subgroup (183 cases).ResultsThe prevalence of NAFLD by Abdominal ultrasonography was 68%.The results indicated that the levels of 25-(OH) D were significantly lower in T2DM with NAFLD group than that in simple T2DM group(P < 0.01). The levels of 25-(OH) D were significantly lower in progressive liver fibrosis subgroup than that in patients without progressive liver fibrosis and simple T2DM,and 25-(OH) D levels were lower in without progressive liver fibrosis subgroup than that in simple T2DM group(p < 0.01 or p < 0.05). Multivariate logistic regression analysis showed that levels of 25-(OH) D were negative correlation with risk of NAFLD and progressive liver fibrosis(p = 0.011、p = 0.044,respectively).Conclusionswe could come to a conclusion that low levels of 25-(OH) D was a risk factor for NAFLD and progressive liver fibrosis in T2DM patients.
Highlights
It is widely acknowledged that nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus(T2DM) are all chronic metabolic diseases
Alanine aminotransferase (ALT), aspartic acid aminotransferase (AST) and glutamyltransferase (GGT) were detected by rate method;The HMMPS method for the determination of creatinine (CR);Uric acid (UA) was detected by uricase method; Bromocresol green method for the determination ofalbumin (ALB); Fasting blood glucose (FBG) was measured by hexokinase method;Triglycerides were detected by GPO enzyme reagent method;Enzymatic oxidation of cholesterol for the determination of total cholesterol (TC);Antibody blocking method for the determination of high density lipoprotein (HDL);Choice protection method for the determination of low density lipoprotein (LDL);Transmissivity turbidimetry method for the determination of cystatin C (CysC);Fasting C-peptide (FCP) was detected using magnetic particle chemiluminescence method
Values of BMI,waist circumference, ALT, Asparticacid aminotransferase (AST), GGT, fasting blood glucose (FBG), triglyceride (TG), triglyceride (TC), HOMA-insulin resistance (IR) (CP) and HBA1C values were all higher in Type 2 diabetes mellitus (T2DM) with NAFLD group, while creatinine (CR), CysC, high density lipoprotein (HDL) and 25-(OH) D levels were significantly lower among the T2DM combined-NAFLD group than simple T2DM group
Summary
It is widely acknowledged that nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus(T2DM) are all chronic metabolic diseases. Zhang et al BMC Endocrine Disorders (2021) 21:100 existence of liver fibrosis in NAFLD patients. This scoring system is non-invasive, which makes up for the defect of using invasive liver biopsy in the past. Clinical studies [13] found that the low levels of 25-(OH) D were related to the occurrence of progressive liver fibrosis. Vitamin D plays an important role in altering the risk of T2DM, such as mediating β -cell function, insulin sensitivity, and systemic inflammation [16]. On the basis of the controversy over the relationship between vitamin D and NAFLD,and few studies are conducted on that population of T2DM combined with NAFLD, so we aimed to explore the relationship between 25-(OH) D and NAFLD by observing serum 25-(OH) D levels in patients with T2DM in this study
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