Correlation study on susceptible genes of obsessive compulsive disorder of Han population in northeast China

Abstract

Objective To explore the relationship between Monoamine oxidase A (MAOA) receptor gene, catechol-O- methyltransferase(COMT)receptor gene, dopamine D3 receptor(DRD3)gene and 5-HT2C receptor gene(5-HT2c) of Han population in northern China and obsessive compulsive disorder. Methods Polymerase chain reaction amplification determination of MAOA-T1460C, COMT-Val158Met, DRD3-Ser9Gly, 5-HT2c-C ys23Ser four loci receptor gene polymorphism in 164 patients with OCD patients including 103 core pedigrees of fragment length polymorphism, and association and linkage disequilibrium(TDT)analysis. Results There was no significant difference of MAOA-T1460C, COMT-Val158Met, DRD3-Ser9Gly, 5-HT2c-Cys23Ser four receptor gene in the patient group and the control group of genotype and allele distribution difference(P>0.05), four receptor gene loci were in accordance with the balance of the H-W, the MAOA-T1460C receptor gene in female patients group and control group, the early group and control group, which has forced thinking and difference of compulsive behavior group and the control group, only the obsessional group and the control group of genotype and allele distribution was statistically significant(P 0.05), and with the house group does not exist between the chain (P=0.0622); DRD3-Ser9Gly receptor gene in the control experiments were no significant difference(P>0.05), and with the family groups there is no chain(P=0.1101). Conclusion MAOA-T1460C receptor gene polymorphism and 5-HT2c-Cys23Ser receptor gene polymorphisms may be the susceptible gene of obsessive compulsive disorder. Key words: Obsessive-compulsive disorder; Gene; Monoamine oxidase A receptor; Catechol-O- methyl transferase receptor; Dopamine D3 receptor; 5-serotonin 2C receptor; Association study