Abstract
Objective To investigate the expression of STAT3 (signal transducers and activators of transcription-3) and phosphorylated STAT3 in patients of cerebral arteriovenous malformation (AVM).Methods 35 patients who underwent cerebral AVM removal had been enrolled in this study.Five patients who underwent decompression for brain trauma were normal control.The resected AVM nidus and control tissue were under immunohistochemisty analysis for STAT3,P-STAT3(Tyr705) and P-STAT3(Ser727).Results The expression of STAT3,P-STAT3 (Tyr705) and P-STAT3 (Ser727) were 100％ (35/35),74％ (24/35) and 77％ (24/35) respectively in AVM group.except weakly positive express of STAT3 in two patient,P-STAT3 (Tyr705) and P-STAT3 (Ser727) were all negative in control group.the expression of P-STAT3 (Tyr705) showed more intensive level in thrombosis group than unthrombosis group (P ＜ 0.05).Conclusions STAT3 was overexpressed and activated in cerebral AVM.The activation of STAT3 signal transduction way may mediate the blood vessels remolding and neovasculization in cerebral AVM.Thrombosis maybe increase STAT3 phosphorylation. Key words: Cerebral arteriovenous malformation; Signal transducers and activators of transcription-3 ; Immunohistochemistry
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