Correlation relationship between cadmium accumulation and histological structures of ovary and uterus in rabbits

Abstract

Cadmium accumulation in ovaries and uterus after i.p. and p.o. administration are reported. Time and dose dependent increase in cadmium concentration was found. More than 10 times higher accumulation is after i.p. administration in comparison with p.o. administration in ovaries as well as in uterus. There is very high correlation relationship among growing follicles and stroma in general as well as in all groups. So, we can report that with the increasing number of growing follicles there is lower amount of stroma. Generally we have found mean correlation relationship among cadmium content in ovaries and the percentual amount of growing follicles and stroma. We can say that with higher cadmium content in ovaries there is lower amount of primary follicles and stroma, but more growing follicles. On the other hand our previous study have described higher incidence of follicular atresia, which affect mainly growing follicles. In evaluation of numer of ovarian follicles to cadmium content, we report that generally there is mean correlation relationship among cadmium content and follicles with less than 2 layers of granulosa cells. This study also reports correlation relationship between cadmium content in ovary and diameter of follicles. Generally we can conclude, that the correlation relationship is very low and cadmium do not affect the diameter of follicles. Correlation analysis shows that there is mean relationship between cadmium content in uterus and stroma in endometrium. With higher cadmium content there is more stroma, what is a sign of oedematizatization.