Abstract

IntroductionThe humoral response to vaccinations varies widely between individuals. There is no data available on the correlation between responses to different vaccines. In this study, we investigated the correlation of antibody responses between routine vaccine antigens in infants.MethodsOne and seven months after the 6-month vaccinations and one month after the 12-month vaccinations, antibody concentrations to diphtheria, tetanus, pertussis, polio (serotypes 1-3), Haemophilus influenzae type b (Hib), pneumococcus (13 serotypes), meningococcus C, measles, mumps and rubella were measured using fluorescent bead-based multiplex immune-assays. For the correlation of antibody responses, Spearman’s rank correlation coefficients (ρ) with 95% confidence intervals (CI) were calculated between responses to each vaccine antigen.ResultsThe correlation between concentrations of antibodies to the vaccinations ending at 6 months of age was higher one month compared to seven months after vaccination. The strongest correlations at both time points were observed between antibody responses to different polio serotypes, certain pneumococcal serotypes and between responses to diphtheria and pneumococcal (conjugated to a diphtheria toxoid) vaccine antigens. Correlation between responses to tetanus, Hib, pertussis, polio and other vaccine antigens were weak. The correlation between antibody responses to the 12-month vaccine antigens was weaker than to the 6-month vaccine antigens and there was a negative correlation between responses to measles, mumps, rubella vaccine and non-live vaccine antigens (meningococcus C, tetanus and Hib). There was only weak correlation between antibody responses to vaccines of the same type (e.g. conjugated polysaccharide or toxoid vaccines).ConclusionCorrelation between antibody responses to similar antigens in the same vaccine (such as different serotypes of a bacteria or virus), as well as responses to antigens conjugated to similar carrier proteins, are strong. In contrast, correlation between responses to other vaccines are weak. Measuring antibody responses to one or a few vaccine antigens therefore does not offer a reliable surrogate marker of responses to unrelated vaccines.

Highlights

  • The humoral response to vaccinations varies widely between individuals

  • 91 participants had antibody responses to their 6-month vaccinations measured one month after vaccination and 141 participants seven months after vaccination

  • Antibody responses in individuals one and seven months after 6-month vaccinations are shown in Figures 1 and 2

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Summary

Introduction

The humoral response to vaccinations varies widely between individuals. There is no data available on the correlation between responses to different vaccines. There are many different methods to quantify the immune response to vaccines, including measuring innate, humoral, cellular and cytokine responses. The magnitude of response is influenced by the type of vaccine. Live attenuated vaccines induce strong antibody responses, similar to infection with a wild-type pathogen, leading to induction of memory cells and often lifelong protection. Inactivated, subunit or toxoid vaccines induce lower responses, requiring booster doses. The response to different subunit vaccines varies: polysaccharide-protein conjugated vaccines have superior immunogenicity (including the induction of long-term protection) compared with polysaccharide vaccines which only induce short-lived T cell-independent antibody responses [2]

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