Abstract
Thirty-three patients underwent 79 simultaneous calcium 47 kinetic and calcium, phosphorus and nitrogen metabolic balance studies. Concomitantly, total urinary hydroxyproline and serum alkaline phosphatase were determined. The group was weighted in favor of patients with osteoporosis, vitamin D-resistant rickets, metastatic bone disease and parathyroid disorders. Total urinary hydroxyproline, serum alkaline phosphatase, calcium accretion rate and calcium resorption rate correlate well among the metabolic bone disease groups. There is a good correlation in a given individual between serum alkaline phosphatase and calcium accretion rate and between urinary hydroxyproline and calcium resorption rate. The combination of serum alkaline phosphatase and urinary hydroxyproline is a useful screening method for the detection of skeletal diseases with high turnover rates.
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