Abstract
To compare the diagnostic efficacy of iteratively restored tuned aperture computed tomography (TACT) with conventional computed tomography (CT) for evaluation of osseous healing in induced calvarial defects. Fifty-six calvarial defects in 14 rabbits received 1 of 4 possible treatments: copolymer membranes with and without bone marrow stromal cells (BMSCs), BMSCs alone, or no treatment (control). Healing was measured after 2, 4, and 8 wks as remaining defect areas measured on TACT and CT images. Histomorphometric analyses were done on the specimens. Bone formation was minimal to none in control defects and those treated with BMSCs or polymer matrices alone. Healthy bone formation was noted in defects treated with polymers impregnated with BMSCs. Unresolved defect area measurements using TACT and CT of osseous healing showed a high positive correlation. Potential for TACT to accurately detect osseous healing in surgical defects was demonstrated. High resolution of TACT combined with generation of information in 3D yields comparable performance to CT.
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