Correlation of tumor necrosis factor alpha (TNF-α) with thyroid hormones (TSH, Free T3 & Free T4) in the patients of subclinical hypothyroidism

Abstract

Background: Subclinical hypothyroidism is a minor form of hypothyroidism caused by a high TSH level. TNF-α one of the suggested parameters to detect thyroid disorders, it is involved in various purposes such as inflammatory skin disease, cardiovascular function, endothelial dysfunction etc. Objective: The goal of this research was to determine the relationship between Tumor necrosis factors-α and thyroid profile in subclinical hypothyroidism, including its predictive value. Method: The current study included 200 patients and 200 controls who consulted the outpatient departments of Shri Guru Ram Rai Institute of Medical and Health Sciences in Dehradun and Rohilkhand Medical College Hospital in Bareilly. These participants' biochemical parameters (TSH, FT3, FT4, & TNF-) were investigated using the ELISA method. Result: TNF-α level was found to be comparatively greater in cases (mean ± SD value- 38.66 ±37.59) of subclinical hypothyroidism as compared to controls (mean ± SD value- 3.47±3.29) in the study. Conclusion: The current investigation found that TNF- played a significant role. TNF- α effective marker to find out the thyroid disorder but TSH is far more effective than TNF-α to detect thyroid abnormalities.