Abstract
Hematoporphyrin derivative (HPD) photodynamic therapy (PDT) has proved effective in the treatment of selected neoplasms (1). The effectiveness of this form of therapy rests on the retention of the systemically administered HPD in neoplastic tissue and its photoactivation with visible light resulting in ‘photodynamic’ tumor destruction. Although it is generally agreed that singlet oxygen liberated during HPD-photodynamic therapy is responsible for the biologic damage created by PDT, the mechanisms of cell death have not been clearly defined (2). Previous studies in our laboratory have demonstrated a rapid and sustained decrease in tumor blood flow after HPD-photodynamic therapy (3,4). The present study was undertaken to correlate changes in tumor blood flow with tumor regression after HPD-PDT.
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