Abstract
Introduction: Chronic kidney disease (CKD) is an international public health problem affecting about 5–10% of the population. It is the ninth leading cause of death. A trend towards increased incidence and prevalence is being reported worldwide with epidemic proportions in many countries. CKD is associated with variety of endocrine disturbances among which thyroid dysfunction is most common. This is probably due to reduce circulating hormone levels, altered binding of hormone to carrier protein or due to reduced peripheral metabolism of hormone.
 Materials and Methods: The study included 100 patients diagnosed with CKD. Both male and female patients aged between 30-70 years were selected for the study. Estimated Glomerular Filtration Rate (eGFR) was calculated using Modification of Diet in Renal Disease (MDRD) formula. Total T3, Total T4, TSH levels were measured by CLIA methodology.
 Results: Statistically significant alteration in TSH (p<0.01) values were seen with eGFR suggesting that alteration in the eGFR may lead to thyroid hormone resistance.
 Keywords: Chronic Kidney Disease(CKD), Estimated Glomerular Filtration Rate (eGFR), Modification of Diet in Renal Disease (MDRD)
Highlights
Chronic kidney disease (CKD) is an international public health problem affecting about 5–10% of the population
Statistically significant alteration in thyroidstimulating hormone (TSH) (p
Similar findings were documented by Lim et al, who found that the prevalence of hypothyroidism in End stage renal disease was 0–58% and of Sub clinical hypothyroidism is 0–9.5% [17]
Summary
Chronic kidney disease (CKD) is an international public health problem affecting about 5–10% of the population. It is the ninth leading cause of death. CKD is associated with variety of endocrine disturbances among which thyroid dysfunction is most common This is probably due to reduce circulating hormone levels, altered binding of hormone to carrier protein or due to reduced peripheral metabolism of hormone. Chronic kidney disease (CKD) is a progressive disease causing an irreversible damage in kidney function It is a problem in both industrialised and developing countries of the world, having ranked 13th leading cause of death worldwide in 2013. The response of thyroidstimulating hormone (TSH) to thyrotropin-releasing hormone is delayed because of the decreased clearance and the increase of half-life of TSH [4]
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