Correlation of Thyroid Hormone Derangement with Serum Ferritin Level in Children with Beta Thalassaemia Major at a Tertiary Care Hospital of Bangladesh

Abstract

Background: Thalassaemia is a heterogeneous group of disorders. In multi-transfused thalassaemia major patients the thyroid gland function has been reported to be normal, decreased reserve, or primary hypothyroidism.Objective: This study was an attempt to know the thyroid function status in multi-transfused thalassaemic patients and it's correlation with iron overload.Methods: This cross sectional study was carried out in the Department of Pediatrics at Bangabandhu Sheikh Mujib Medical University (BSMMU) and Transfusion centre of Bangladesh Thalassaemia Samity, Dhaka during May 2011 to April 2012. Previously diagnosed cases of thalassaemia major patients with transfusion dependent at any age with both sexes were randomly selected for this study. Serum total thyroxine (T4), total triiodothyronine (T3), thyroid stimulating hormone (TSH) and serum ferritin level were estimated from venous blood.Results: A total of 50 previously diagnosed cases of thalassaemia major patients of which 30 male and 20 female of 4 to 15 years age, transfusion dependent were randomly selected for this study. Hypothyroidism was present in 10(20%) patients. Among these 10 patients compensated primary hypothyroidism was in 5(10%) cases and decompensate primary hypothyroidism was 5(10%) cases. The TSH value of hypothyroid patients was higher. Serum ferritin value was significantly higher in all the three groups of thalassaemic patients. There was no significant correlation between the high serum ferritin value with thyroid stimulating hormone or serum total thyroxin level.Conclusion: All transfusion dependent thalassaemic patients need periodic evaluation of thyroid function because there was incidence of hypothyroidism.DOI: http://dx.doi.org/10.3329/jssmc.v5i2.20762J Shaheed Suhrawardy Med Coll 2013;5(2):87-90]