Correlation of the levels of serum betatrophin, adiponectin, and interleukin-1β in newly diagnosed type 2 diabetes with different stages of urinary albumin

Abstract

267 newly-diagnosed patients with type 2 diabetes were divided into normoalbuminuria group[group N-UAlb, urinary albumin to creatinine ratio (UACR) 300 mg/g, n=76). The control group(group NC)consisted of 114 healthy individuals. Serum betatrophin, adiponectin(APN), and interleukin-1β(IL-1β)levels were determined with ELISA methods and the parameters of body mass index(BMI), estimated glomerular filtration rate(eGFR), HbA1C,fasting plasma glucose(FPG), OGTT 2h plasma glucose(2hPG), fasting insulin(FINS), OGTT 2h postprandial insulin(2hPINS), fasting C-peptide(FCP), homeostasis model assessment insulin resistant index(HOMA-IR), and blood lipid were collected. Compared with group NC, the serum betatrophin levels in patients with type 2 diabetes were obviously increased. In patients with type 2 diabetes, betatrophin levels increased along with the increase of UACR and there were significant differences in betatrophin among the three groups(P<0.01). Betatrophin positively correlated with UACR, HbA1C,FPG, 2hPG, FINS, 2hPINS, HOMA-IR, TC, LDL-C, and TG(r were 0.785, 0.225, 0.136, 0.241, 0.386, 0.223, 0.411, 0.216, 0.193, and 0.298, all P<0.05), and betatrophin were also positively correlated with APN and IL-1β(r were 0.643 and 0.710, both P<0.01). Stepwise multiple regression analysis showed that UACR, HbA1C,FINS, and TG were independent relevant factors affecting betatrophin levels. (Chin J Endocrinol Metab, 2017, 33: 116-119) Key words: Diabetes mellitus, type 2; Betatrophin; Adiponectin; Interleukin-1β; Albuminuria